Publications

これまでに発表した論文（以前に所属していた研究室で発表したものも含みます）を紹介しています。

それぞれの論文のAbstractは末尾の[PubMed]などのリンクをクリックしていただければ、NCBI PubMedの抄録ページ等に移ります。

原著論文 Original Papers

  1. He X, Kusuya Y, Hagiwara D, Toyotome T, Arai T, Bian C, Nagayama M, Shibata S, Watanabe A, Takahashi H "Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance", Commun. Biol., 7, 274, 2024[PubMed]

  2. Fujiwara T, Itoh M, Matsumoto N, Koshizaki Y, Saitou S, Yamada K, Toyotome T "Most azole-susceptible isolates of Aspergillus fumigatus in Hokkaido, Japan are clustered with worldwide strains that do not have tandem repeats in cyp51A promoter", Medical Mycology Journal, 65, 13-15, 2024[PubMed]

  3. Matsumoto N, Itoh M, Toyotome T, Hagino K, Neo S, Yamada K "Usefulness of combining computed tomography and air sac fluid examination to rule out aspergillosis: Case study in two gentoo penguins (Pygoscelis papua) with respiratory clinical signs", Mycopathologia 2024, 189.[PubMed]

  4. Rivelli Zea SM, Itoh M, Toyotome T "Development of Loop-Mediated Isothermal Amplification for the Detection of Prototheca bovis Directly from Milk Samples of Dairy Cattle", Mycopathologia, 189, 2024.[PubMed]

  5. Oguma T, ..., Toyotome T, ..., Asano K, Japan ABPM Research Program "Clinical characteristics of allergic bronchopulmonary mycosis caused by Schizophyllum commune", Clin. Transl. Allergy, 2024.[Wiley]

  6. 清水貴瑛, 上川昭博, 豊留孝仁, 高橋英二, 古岡英文 "Prototheca属4種を用いたマウス乳房炎モデルの病理学的解析", 帯広畜産大学学術研究報告 2023, 44, 1-10. [Obihiro University Archives of Knowledge]

  7. Toyotome T "Further Evaluation of in Vitro Assay of Translation Inhibition Using Three Modified Deoxynivalenol Compounds", JSM Mycotoxins 2023, 73, 61-63.[J-Stage]

  8. Itoh M, Matsumoto N, Hagino K, Sawayama N, Kuwayama M, Yamada K, Toyotome T "Nationwide Survey about the Occurrence of Aspergillosis in Captive Penguins in Zoos and Aquariums in Japan", Animals, 13, 1913, 2023[Animals (MDPI)]

  9. Toyotome T, Matsui S. "Analysis of Prototheca and yeast species isolated from bulk tank milk collected in Tokachi District, Japan", J. Dairy Sci., 105, 8364-8370, 2022[Elsevier]

  10. Mikami N, Toyotome T, Takaya M,Tamura K. "Direct Rub Inoculation of Fungal Flora Changes Fatty Acid Composition and Volatile Flavors in Dry-Aged Beef: A Preliminary Study", Animals, 12, 1391, 2022[PubMed]

  11. Matsumoto N, Sawayama N, Itoh M, Toyotome T, Yamada K. "Evaluation of the air sac volume of penguins with respiratory diseases using computed tomography", J. Vet. Med. Sci., 84, 368-372, 2022 [PubMed]

  12. Toyotome T, Kamei K. "In Vitro Assay of Translation Inhibition by Trichothecenes Using a Commercially Available System", Toxins, 13, 696, 2021[PubMed]

  13. Toyotome T, Onishi K, Sato M, Kusuya Y, Hagiwara D, Watanabe A, Takahashi H. "Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole", Antimicrob. Agents Chemother., 65, e0265720, 2021[PubMed]

  14. Toyotome T, Takino M, Takaya M, Yahiro M, Kamei K. "Identification of Volatile Sulfur Compounds Produced by Schizophyllum commune", J. Fungi, 7, 465, 2021[PubMed]

  15. Mikami N, Toyotome T, Yamashiro Y, Sugo K, Yoshitomi K, Takaya M, Han K-H, Fukushima M, Shimada K. "Dry-aged beef manufactured in Japan: Microbiota identification and their effects on product characteristics", Food Res. Int., 140, 110020, 2021[PubMed]

  16. 松本直也, 伊藤めぐみ, 山田一孝, 豊留孝仁. "一水族館における飼育環境中のAspergillus fumigatus検出およびペンギンのアスペルギルス症根絶を導いた予防対策", 日本野生動物医学会誌, 25, 101-107, 2020[J-Stage]（日本野生動物医学会論文賞受賞）

  17. Takeshige A, Nakano M, Kondoh D, Tanaka Y, Sekiya A, Yaguchi T, Furuoka H, Toyotome T. "Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model", Vet. Res., 51, 119, 2020 [Vet. Res. article page]

  18. Itoh M, Toyotome T, Matsumoto N, Okamoto M, Watanabe K-I, Yamada K. "Characteristic imaging findings of the respiratory system in penguins with suspected aspergillosis in an aquarium", J. Vet. Med. Sci., 82, 1260-1266, 2020 [PubMed]

  19. 松井李穂, 大橋英二, 松本高太郎, 豊留孝仁. "猫の鼻腔からSchizophyllum communeが検出された1症例", 北海道獣医師会雑誌, 64, 180-184, 2020[論文PDFへの直接リンクです]

  20. Ohki Y, Okamoto Y, Iinuma T, Yamamoto H, Toyotome T, Yahiro M, Yonekura S, Sakurai D, Kamei K. "Local Fungus-Specific Immunoglobulin E Production in Chronic Rhinosinusitis With Nasal Polyps", Rhinology, 58, 136-144, 2020 [PubMed]

  21. Toyotome T, Arai T, Watanabe A, Kamei K. "Detection of Substitutions at 98th, 121st, and 289th Amino Acid Residues in Cyp51A using Cycling Probes", Med. Mycol. J., 61, 7-10, 2020 [PubMed]

  22. Yamada K,Toyotome T, Matsumoto N, Itoh M. "Autopsy imaging for aspergillosis in King Penguin, an economically valuable zoo animal.", J. Vet. Med. Sci., 82, 373-375, 2020 [PubMed]

  23. Toyotome T, Saito S, Koshizaki Y, Komatsu R, Matsuzawa T, Yaguchi T. "Prospective survey of Aspergillus species isolated from clinical specimens and their antifungal susceptibility: A five-year single-center study in Japan", J. Infect. Chemother., 26, 321-323, 2020 [PubMed]

  24. 堀江祐範, 西岡浩貴, 多田敦美, 杉野紗貴子, 水野智文, 豊留孝仁, 岩橋均. "バタバタ茶の発酵に関与する微生物", 美味技術学会誌, 18, 62-70, 2019

  25. Hanashiro J, Muraosa Y, Toyotome T, Hirose K, Watanabe A, Kamei K. "Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice", Sci. Rep., 9, 19321, 2019 [PubMed]

  26. Horie M, Tada A, Kanamoto N, Tamai T, Fukuda N, Sugino S, Toyotome T, Tabei Y. "Evaluation of lactic acid bacteria and component change during fermentation of Ishizuchi-kurocha", J. Food Process. Preserv., 43, e14186, 2019 [Wiley]

  27. Yamamoto M, Horie M, Fukushima M, Toyotome T. "Culture-based analysis of fungi in leaves after the primary and secondary fermentation processes during Ishizuchi-kurocha production and lactate assimilation of P. kudriavzevii", Int. J. Food Microbiol., 306, 108263, 2019 [PubMed]

  28. Toyotome T, Yamamoto M, Horie M. "Draft Genome Sequence of the Yeast Pichia manshurica YM63, a Participant in Secondary Fermentation of Ishizuchi-Kurocha, a Japanese Fermented Tea", Microbiol. Resour. Announc., 8, e00528-19, 2019 [PubMed]

  29. Muraosa Y, Toyotome T, Yahiro M, Kamei K. "Characterisation of novel-cell-wall LysM-domain proteins LdpA and LdpB from the human pathogenic fungus Aspergillus fumigatus", Sci. Rep., 9, 3345, 2019 [PubMed]

  30. Toyotome T, hamada S, Yamaguchi S, Takahashi H, Kondoh D, Takino M, Kanesaki Y, Kamei K. "Comparative genome analysis of Aspergillus flavus clinically isolated in Japan", DNA Res., 26, 95-103, 2019 [PubMed]

  31. Horie M, Sato H, Tada A, Nakamura S, Sugino S, Tabei Y, Katoh M, Toyotome T. "Regional characteristics of Lactobacillus plantarum group strains isolated from two kinds of Japanese post-fermented teas, Ishizuchi-kurocha and Awa-bancha", Biosci. of Microbiota Food Health, 38, 11-22, 2019 [PubMed]

  32. Tanaka Y, Toyotome T, Inokuma H, Watanabe K, Kobayashi Y, Horiuchi N. "Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves", Mycopathologia, 184, 141-146, 2019 [PubMed]

  33. 田中佑典, 豊留孝仁, 猪熊壽, 片山享輔, 渡邉謙一, 堀内雅之, 古林与志安. "接合菌が肝臓に壊死桿菌症様病巣を形成した黒毛和種子牛の1例", 北海道獣医師会雑誌, 62, 20-23, 2018 [論文PDFへの直接リンクです]

  34. Nakagun S, Okazaki M, Toyotome T, Sugiyama N, Watanabe K, Horiuchi N, Kobayashi Y. "Fatal Pulmonary and Cerebellar Zygomycosis due to Rhizomucor pusillus in a Ringed Seal (Pusa hispida)", Mycopathologia, 183, 979-985, 2018 [PubMed]

  35. Toyotome T, Hagiwara D, Watanabe A, Kamei K. "A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus", Med. Mycol., 56, 1042-1044, 2018 [PubMed]

  36. Takahashi-Nakaguchi A, Sakai K, Takahashi H, Hagiwara D, Toyotome T, Chibana H, Watanabe A, Yaguchi T, Yamaguchi M, Kamei K, Gonoi T. "Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses", Cell. Microbiol., 20, e12802, 2018 [PubMed]

  37. 中野美絵，山口英美，木元美樹，崔宝隠，松本高太郎，豊留孝仁，古岡秀文. "北海道十勝地方のエゾリス（Sciurus vulgaris orientis）およびドブネズミ（Rattus norvegicus）に見られたadiaspiromycosisの病理学的検索", Jpn. J. Zoo Wildl. Med., 22, 37-40, 2017 [J-Stage]

  38. Onishi K, Sarumoh BM, Hagiwara D, Watanabe A, Kamei K, Toyotome T. "Azole-resistant Aspergillus fumigatus containing a 34-bp tandem repeat in cyp51A promoter is isolated from the environment in Japan", Med. Mycol J., 58E, E67-E70, 2017 [PubMed]

  39. Toyotome T, Hagiwara D, Kida H, Ogi T, Watanabe A, Wada T, Komatsu R, Kamei K. "First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan.", J. Infect. Chemother., 23, 579-581, 2017 [PubMed]

  40. Toyotome T, Fujiwara T, Kida H, Matsumoto M, Wada T, Komatsu R. "Azole susceptibility in clinical and environmental isolates of Aspergillus fumigatus from eastern Hokkaido, Japan.", J. Infect. Chemother., 22, 648-650, 2016[PubMed]

  41. Toyotome T, Takahashi M, Kamei K. "MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect.", J. Toxicol. Sci., 41, 25-31, 2016[PubMed]

  42. Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K. "Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR.", Med. Mycol., 54, 433-438, 2016[PubMed]

  43. Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H. "Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis.", Med. Mycol., 53, 353-360, 2015[PubMed]

  44. Toyotome T, Watanabe A, Ochiai E, Kamei K. "N-acetylated α-linked acidic dipeptidase is identified as an antigen of Histoplasma capsulatum.", Biochem. Biophys. Res. Commun., 458, 483-487, 2015[PubMed]

  45. Tamiya H, Ochiai E, Kikuchi K, Yahiro M, Toyotome T, Watanabe A, Yaguchi T, Kamei K. "Secondary metabolite profiles and antifungal drug susceptibility of Aspergillus fumigatus and closely related species, A. lentulus, A. udagawae, and A. viridinutans.", J. Infect. Chemother., 2015[PubMed]

  46. Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M,Sanada T, Suzuki T, Tsutsui H, Nunez G, Sasakawa C. "Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.", Proc. Natl. Acad. Sci. USA, 111, E4254-63, 2014[PubMed]

  47. Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K. "Effect of Serum Components on Biofilm For mation of Aspergillus fumigatus and non-fumigatus Aspergillus.", Jpn. J. Infect. Dis., 67, 172-179, 2014[PubMed]

  48. Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K. "GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.", Med. Mycol., 52, 506-518, 2014[PubMed]

  49. Toyotome T, Satoh M, Yahiro M, Watanabe A, Nomura F, Kamei K. "Glucoamylase is a major allergen of Schizophyllum commune.", Clin. Exp. Allergy, 44, 450-457, 2014[PubMed]

  50. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S. "NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus.", PLoS One, 8, e80881, 2013[PubMed]

  51. Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K. "Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus.", Int. J. Med. Microbiol., 302, 108-16, 2012[PubMed]

  52. Nagayoshi M, Tada Y, West J, Ochiai E, Watanabe A, Toyotome T, Tanabe N, Takiguchi Y, Shigeta A, Yasuda T, Shibuya K, Kamei K, Tatsumi K. "Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.", Mycopathologia, 172, 5-15, 2011[PubMed]

  53. Oarada M, Kamei K, Gonoi T, Tsuzuki T, Toyotome T, Hirasaka K, Nikawa T, Sato A, Kurita N. "Beneficial effects of a low-protein diet on host resistance to Paracoccidioides brasiliensis in mice.", Nutrition, 25, 954-963, 2009[PubMed]

  54. Toyotome T, Adachi Y, Watanabe A, Ochiai E, Ohno N, Kamei K. "Activator protein 1 is triggered by Aspergillus fumigatus beta-glucans surface-exposed during specific growth stages.", Microb. Pathog., 44, 141-150, 2008[PubMed]

  55. Ashida H, Toyotome T, Nagai T, Sasakawa C. "Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors.", Mol. Microbiol., 63, 680-693, 2007[PubMed]

  56. Oarada M, Gonoi T, Tsuzuki T, Igarashi M, Hirasaka K, Nikawa T, Onishi Y, Toyotome T, Kamei K, Miyazawa T, Nakagawa K, Kashima M, Kurita N. "Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice.", Biosci. Biotechnol. Biochem., 71, 174-182, 2007[PubMed]

  57. Suzuki T, Yoshikawa Y, Ashida H, Iwai H, Toyotome T, Matsui H, Sasakawa C. "High vaccine efficacy against shigellosis of recombinant noninvasive Shigella mutant that expresses Yersinia invasin.", J. Immunol., 177, 4709-4717, 2006[PubMed]

  58. Okuda J, Toyotome T, Kataoka N, Ohno M, Abe H, Shimura Y, Seyedarabi A, Pickersgill R, Sasakawa C. "Shigella effector IpaH9.8 binds to a splicing factor U2AF35 to modulate host immune responses.", Biochem. Biophys. Res. Commun., 333, 531-539, 2005[PubMed]

  59. Tamano K, Katayama E, Toyotome T, Sasakawa C. "Shigella Spa32 is an essential secretory protein for functional type III secretion machinery and uniformity of its needle length.", J. Bacteriol., 184, 1244-1252, 2002[PubMed]

  60. Toyotome T, Suzuki T, Kuwae A, Nonaka T, Fukuda H, Imajoh Ohmi S, Toyofuku T, Hori M, Sasakawa C. "Shigella protein IpaH9.8 is secreted from bacteria within mammalian cells and transported to the nucleus.", J. Biol. Chem., 276, 32071-32079, 2001[PubMed]

総説・プロシーディング Reviews and Proceedings

  1. 荒井千種、木村香澄、岡田聖恵、田中伊万里、豊留孝仁 "黒毛和種去勢牛におけるRhizomucor pusillusによるムーコル症の一例", 獣医公衆衛生研究. 2023, 26, 28-31.

  2. 渡辺麻衣子, 豊留孝仁 "真菌がヒトの生活に及ぼす健康影響", 日本防菌防黴学会誌 2023, 51, 395-404.

  3. Toyotome T, Matsumoto N, Itoh M, Yamada K. "Countermeasures Against Aspergillosis in Captive Penguins: Multidisciplinary Approach as One Aspergillosis Control Team", Med. Mycol. J., 63, 49-52, 2022 [J-Stage]

  4. Rivelli Zea SM, Toyotome T. "Azole-resistant Aspergillus fumigatus as an emerging worldwide pathogen", Microbiol. Immunol., Online ahead of print.[PubMed]

  5. Toyotome T. "Resistance in the Environmental Pathogenic Fungus Aspergillus fumigatus", Medical Mycology Journal, 60, 61-63, 2019 [J-Stage]

  6. Toyotome T, Hagiwara D, Takahashi H, Watanabe A, Kamei K. "Emerging Antifungal Drug Resistance in Aspergillus fumigatus and Among Other Species of Aspergillus", Current Fungal Infection Reports, 12, 105-111, 2018 [Springer]

  7. 高橋（中口）梓，萩原大祐，高橋弘喜，酒井香奈江，豊留孝仁，渡辺哲，亀井克彦，五ノ井透. "次世代シークエンサーを活用したオミクス解析によるAspergillus fumigatus病原因子探索", Medical Mycology Journal, 59J, J35-J40, 2018 [J-Stage] 日本語総説です

  8. 豊留孝仁. "原因真菌から見たアスペルギルス症", Medical Mycology Journal, 57J, 149J-154J, 2016 [J-Stage]日本語総説です

  9. 豊留孝仁. "アスペルギルス症におけるグリオトキシンの寄与", JSM Mycotoxins, 65, 109-113, 2015 [J-Stage]日本語プロシーディングです

  10. 亀井克彦, 渡辺哲, 豊留孝仁. "マルネッフェイ型ペニシリウム症", 別冊日本臨牀. 新領域症候群シリーズNo.24. 「感染症症候群（第2版　上　病原体別感染症編」, p.606-608, 2013

  11. 渡辺哲, 豊留孝仁, 亀井克彦. "アスペルギルス症－最近の知見　－成立メカニズム解明とその応用－", 小児内科, 44, 1012-1015, 2012

  12. 豊留孝仁, 亀井克彦, "病原真菌の病原機構と病原因子", 化学療法の領域, 28巻, 201-207, 2012

  13. Toyotome T, Watanabe A, Iwasaki A, Kamei K. "[Strategy of Aspergillus fumigatus to evade attacks from host--projectile weapons and armor]", Nippon. Ishinkin. Gakkai. Zasshi., 50, 139-145, 2009[PubMed]日本語総説です

  14. 豊留孝仁, 渡辺哲, 亀井克彦. "ゲノムプロテオーム解析による真菌病原因子の解明と抗真菌薬創薬への期待", 日本臨牀, 66巻, 2255-2260, 2008[PubMed]

  15. Watanabe A, Hashimoto Y, Higurashi H, Ochiai E, Toyotome T, Nagayoshi M, Kamei K. "[Candidates for virulence factors of Aspergillus fumigatus]", Nippon. Ishinkin. Gakkai. Zasshi., 49, 263-267, 2008[PubMed]日本語総説です

  16. 渡辺哲, 豊留孝仁, 亀井克彦. "ヒストプラズマ症", 別冊日本臨牀. 新領域別症候群シリーズNo.8. 「呼吸器症候群（第2版）. I. -その他の呼吸器疾患を含めて-. I. 感染症呼吸器疾患. D. 真菌感染症」 p.184-187, 2008

著書 Books

  1. 豊留孝仁（分担）. "第14章　真菌学　1. 真菌とは（p.458-465）", 「獣医微生物学　第4版」, 公益社団法人　日本獣医学会　微生物学分科会　編，関崎　勉／遠矢幸伸／福士秀人／堀本泰介／村瀬敏之　編集，文永道堂出版，2018年6月発行 文永堂出版サイト

その他 others

  1. 豊留孝仁, 伊藤めぐみ. "技術ワイド　乳房炎対策を見直し損失抑える　現場での活用目指した簡易検査キット", デーリィマン, 4月号, 42-44, 2023

  1. 豊留孝仁. "教育コラム　屋外環境で広がっているクスリの効かない病原アスペルギルス", かびと生活, 14, 31-34, 2021

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